Pharmacokinetic study of rational regimen of oral clindamycin in comparison with doxycycline in mild cases of acne vulgaris

Background: Acne vulgaris is a chronic inflammatory disease of pilosebaceous units. It is a common skin disorder affecting both boys and girls in the adolescent age group and also extends into the post adolescent age group. From time immemorial, various remedies have been suggested and followed by Ayurvedic, Siddha, Unani practitioners and native healers present in various parts of the world. In this study an attempt has been made to evaluate the efficacy of a low dose oral Clindamycin in Acne vulgaris and the results of the study have been presented in ensuing chapters.Methods: The Prospective, Randomized Controlled, Single blind study was conducted in Out Patient Section, Department of Dermatology, tertiary care teaching hospital September 2016 to May 2017 for Total six weeks. Drug administration - four weeks. Follow up - two weeks mostly drug used Capsule Clindamycin 50mg. Capsule Doxycycline 100 mg. Benzoyl Peroxide 5% topical cream.Results: The objective of the study is not only to find out the efficacy of a low dose of 50 mg Clindamycin given orally, but also to find out if this efficacy is obtained without producing the adverse effects for which the administration of Clindamycin is hesitated the ant-microbial, Cap. Doxycycline and Cap. Clindamycin act in acne vulgaris by their effect on the Propionibacterium acne. These antibiotics decrease the population of Propionibacterium acne which in turn leads to the inhibition of the bacterial lipases and this is followed by a decrease in concentration of free fatty acids. This produces less tissue inflammation and acne.Conclusions: This study proves the safety and efficacy of low dose of oral Clindamycin in acne vulgaris, and such low doses can also be tried for other infections where the causative organism responds to Clindamycin.

Analysis of Inductance Gradient and Current Density Distribution Over Different Cross-section of Rails

In a rail gun system the armature accelerated due to the Lorentz force caused by the current which is diffused in to the rails. The entire system depends on the inductance gradient of the rail which is directly connected to the accelerating performance and efficiency of railgun. Hence, the exact analysis of inductance gradient is extremely significant for the railgun design. Since short duration of current pulse is applied to the rails determination of inductance gradient is very difficult. The inductance gradient varies with the geometric dimensions of the rails and armature. And it can be calculated with analytical method and numerical methods. In this paper inductance gradient of the rail has been computed and compared with the different rail cross-sectional models using Ansoft Maxwell Eddy current solver uses finite element technique to calculate the field distribution in a space. The current density, magnetic flux density, repulsive force acting on the rails also computed to analyze the performance of rail gun

ROLE BASED SECURED ACCESS OF DATA IN CLOUDS

In mobile wireless sensor network, coverage and energyCloud computing is a type of internet-based computing that provides shared computer processing resources and data to computers and other devices on demand. It is a model for enabling ubiquitous, on-demand access to a shared pool of configurable computing resources e.g., computer networks, servers, storage, applications and services, which can be rapidly provisioned and released with minimal management effort. Attribute-based access control defines an access control paradigm whereby access rights are granted to users through the use of policies which combine attributes together. The policies can use any type of attributes such as user attributes, resource attributes, object and environment attributes etc. This model supports Boolean logic, in which rules contain "if-then" statements about who is making the request, the resource and the action. The main problem in attribute–based access control is not having user-centric approach for authorization rules. In ABAC model role hierarchy and object hierarchy is not achieved and restriction in level of expressiveness in access control rules.Secured role-based access control allows managing authorization based on rule-based approach where rules are under the control of data owner and provides enriched role-based expressiveness including role and object hierarchies. Data user without the knowledge of data owner cannot use the cloud server where privilege is provided to data user by data owner. Access control computations are delegated to the cloud service provider, being this not only unable to access the data, but also unable to release it to unauthorized parties. A identity-based proxy re-encryption scheme has been used in order to provide a comprehensive and feasible solution for data centric-approach. Semantic web technologies have been exposed for the representation and evaluation of the authorization model

A SURVEY OF AI IMAGING TECHNIQUES FOR COVID-19 DIAGNOSIS AND PROGNOSIS

The Coronavirus Disease 2019 (COVID-19) has caused massive infections and death toll. Radiological imaging in chest such as computed tomography (CT) has been instrumental in the diagnosis and evaluation of the lung infection which is the common indication in COVID-19 infected patients. The technological advances in artificial intelligence (AI) furthermore increase the performance of imaging tools and support health professionals. CT, Positron Emission Tomography – CT (PET/CT), X-ray, Magnetic Resonance Imaging (MRI), and Lung Ultrasound (LUS) are used for diagnosis, treatment of COVID-19. Applying AI on image acquisition will help automate the process of scanning and providing protection to lab technicians. AI empowered models help radiologists and health experts in making better clinical decisions. We review AI-empowered medical imaging characteristics, image acquisition, computer-aided models that help in the COVID-19 diagnosis, management, and follow-up. Much emphasis is on CT and X-ray with integrated AI, as they are first choice in many hospitals

The physical therapy profile questionnaire (PTPQ): development, validation and pilot testing

<p>Abstract</p> <p>Background</p> <p>Country by country similarities and differences in physical therapy practice exists. Therefore, before updates in practice can be provided, such as trainings in evidence-based practice, it is necessary to identify the profile and nature of practice in a given country or setting. Following a search of the international literature, no appropriate tool was identified to collect and establish data to create the profile of physical therapy practice in the Philippines. We therefore developed, validated and pilot tested a survey instrument which would comprehensively describe the practice of physical therapy in the Philippines</p> <p>Findings</p> <p>We used a mixed methods design to answer our study aims. A focus group interview was conducted among a group of physical therapists to establish the content and contexts of items to be included in the survey instrument. Findings were amalgamated with the information from the literature on developing survey instruments/questionnaires. A survey instrument was drafted and named as the Physical Therapy Profile Questionnaire (PTPQ). The PTPQ was then validated and pilot tested to a different group of physical therapists.</p> <p>The final version consisted of five separate parts namely (A) <it>General information and demographics, (B) Practice Profile, (C) Treatment Preferences, (D) Bases for clinical work and (E) Bases for educational/research work</it>. At present the PTPQ is relevant to the Philippines and could be used by any country which has a similar nature of practice with the Philippines.</p> <p>Conclusion</p> <p>The <it>Physical Therapy Practice Questionnaire (PTPQ) </it>was shown to have good face and content validity among the Filipino physical therapists and their context of practice. It has also been found to be useful, easy to administer tool and in a format appealing to respondents. The PTPQ is expected to assist comprehensive data collection to create a profile of physical therapy practice in the Philippines.</p

Design and Analysis of Fast and Zero Voltage Switching Of Interleaved Flyback Converter with H6 Type Inverter for Photovoltaic Applications

A design and load analysis of interleaved flyback converter with H6 inverter topology is proposed. Flyback converter is one among the DC-DC converter with high frequency which is used or low power applications. Because of high frequency operation switching losses and stresses are more. To reduce stresses and losses across the switch of interleaved flyback converter is proposed. In the grid tied inverter system leakage current is one of the disadvantages and to avoid this H6 type inverter is used. With this advantage of H6 inverter and flyback converter this paper is mainly focused on stresses across switches and eliminating leakage current, harmonic reduction. Further the fast switching is proposed within converter in order to deliver maximum power transfer delivered to load through grid. To validate the overall performance the proposed converter modeled in MATLAB-SIMULINK and prototype developed using DSP DSP TMS320F28377S and connected to grid connected load

Evaluation of the effect of magnesium in combination with organic manures on the growth and yield attributes and yield of cotton (Gossypium hirsutum L.) inTypic Ustropept

Cotton is India's most significant commercial crop and has a significant role in the agricultural economics of the nation. A field experiment was conducted in a farmer’s field located in Achchandavilthan village of Srivillipudhur block, Virudhunager District, from 28-Aug 2019 to Jan, 2020 to evaluate the response of cotton to foliar and soil application of magnesium combination with organic manures on the growth and yield attributes and yield of cotton in magnesium deficient soil. The soil was categorized as “Moderately deep clay Typic Ustropept, and medium N, P and high K content, in a randomized block design with fifteen treatments and three replications. The results revealed that the application of MgSO4 at a rate of 50 kg ha-1 along with 250 kg vermicompost for 30 days (1:5 ratio) at critical stages of crop growth along with the Soil Test Crop Response (STCR) based N,P2O5 and K2O RDF registered the maximum plant height at all three stages (40,70 and harvest) of crop growth (94.7, 122.3 and 222.2 cm), number of monopodial branches plant-1 (33.4), number of sympodial branches plant-1(73.1), numbers of boll plant-1 (48.3), boll weight (3.9 g), and seed cotton yield (26.2 q ha-1). This was followed by treatment (T9) MgSO4 at a rate of 50 kg ha-1 incubated with 500 kg FYM for 30 days (1:10 ratio) along with STCR) based N,P2O5 and K2O RDF and the lowest treatment receiving the recommended dose of N, P2O5 and K2O alone (80:40:40 kg ha1). It was revealed that natural chelated fertilizer prepared from MgSO4 incubated with organic manures for 30 days significantly improved the growth and yield of cotton

Agricultural bio-waste recycling through efficient microbial consortia

In India and other countries, rice straw, a byproduct of rice production, is burned in enormous amounts, which contributes to environmental pollution and climate change by releasing greenhouse gases viz., CO2, N2O, CH4, into the atmosphere. This study aimed to accelerate the degradation of this enormous amount of agricultural biomass via microbial inoculants. Four treatments—rice straw (RS), rice straw plus water (RSW), rice straw plus water plus Pusa decomposer (RSWF), and rice straw plus water plus Tamil Nadu Agricultural University (TNAU) biomineralizer (RSWB) were used in the current investigation. The study's findings demonstrated that rice straw treated with microorganisms decomposed more quickly than RS and RSW treatments. According to EDAX spectra of elemental composition, the carbon content of rice straw in the RS, RSW, RSWF, and RSWB treatments was 33.66%, 29.75%, 13.33%, and 20.65% w/w, respectively. The RSWF treatment of rice straw was found to have the highest nitrogen concentration (0.64% w/w), followed by RSWB (0.61% w/w), RSW (0.45%) w/w, and RS (0.43% w/w). Treatments RSWF and RSWB had lower C/N ratios 20.83, and 33.85, respectively, than that RSW (66.11) and RS (78.28). The RSWF and RSWB treatments' porous, distorted, and rough surface structures provided further evidence that both microbial consortia could decompose rice straw more quickly than the RSW and RS treatments. Therefore, the results of this study imply that rice straw could be added to the soil to improve soil fertility for sustainable crop production rather than being burned

Incidence of respiratory infections and its correlation with smoke exposure among infants from an urban field practice area in Tamil Nadu

Background: Children’s acute lower respiratory infections are most prevalent among new-born. Clinical evaluation and symptoms help to establish the connection between smoke exposure and acute respiratory tract infection (ARTI). Furthermore, there is proof that exposing children to coal smoke considerably increases their risk of developing ARTI. Aims and Objectives: This study was designed to estimate the incidence of respiratory tract infection (RTI) among selected cohort of infants in urban field practice area of Tamil Nadu and to correlate the incidence of RTIs with smoke practices. Materials and Methods: In Tamil Nadu’s urban field practice area, a cohort study of infants was done. A house-to-house survey was conducted and information was gathered among 150 newborns who were tracked after being selected as a period sample based on inclusion criteria at a 15* visit. Numerous data on ARI episodes, housing circumstances, and smoke exposure were gathered and correlated. Software such as Epi info and SPSS version 22 were used to analye data. Results: The incidence of TI was calculated to be 1.7 episodes per 100 person days and 4.7 on average among the 150 newborns chosen. Nearly 48% of people lived in huts, 84% had indoor kitchens, and 75% cooked with gas. Infants who appeared to regularly be exposed to passive smoking have a little increase in the incidence of mean RTI bouts. Conclusion: The additional hospital admissions, which are entirely preventable, place a heavy load on the public health system. It is evident that new initiatives are required to stop infants from being exposed to passive smoke during and after pregnancy. Improving international Electrotechnical commission activities play an active role is reducing incidence of RTIs among infants. Intensified educational interventions on ill effects of indoor and outdoor smoke, passive smoking helps in addressing the issue